Pharmacokinetics & Pharmacodynamics
Pre-Reading
Learning objectives
Other Resources
Study Questions
Use the following practice questions to guide and check your learning
Question #1
Pharmaco____________ is how the body effects a drug
Pharmaco____________ is how a drug effects the body
Question #2
What are the main tenants of pharmacokinetics?
A = ____________________________
D = ____________________________
M = ____________________________
E = _____________________________
Question #3
What are some of the ways that drug absorption differs in pediatric patients?
Oral:
IM:
Topicals:
Question #4
What are some of the ways that drug distribution differs in pediatric patients?
Question #5
Drug metabolism is ______________ in pediatric patients relative to adult patients, partially due to differences in liver enzymes such as CYP450s
a. increased
b. decreased
c. the same
d. variable
Question #6
Important Elimination Equations
What is the name of the common equation used to estimate renal function in adults? ________________
Formula: ________________________________________________________________
What is the name of the common equation used to estimate renal function in children? _________________
Formula: ________________________________________________________________
Question #7
Other Equations
How do you calculate Body Surface Area (BSA)? ____________________________________________
How do you calculate Body Mass Index (BMI)? ___________________________________________
Practice Calculations
1. Calculate the weight-based dose of acetaminophen for a 15 kg patient
2. Calculate the eGFR of the following patient
8-year-old female; Height = 125 cm; Weight = 28kg; SCr = 0.3 mg/dL
3. Calculate the dose of valganciclovir for the following patient (Dose = 7 x BSA x CrCl)
2-year-old male; Height =35 in; Weight = 25 lbs; SCr = 0.8 mg/dL

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