Pharmacokinetics & Pharmacodynamics

Pre-Reading

Learning objectives

Other Resources

Study Questions

Use the following practice questions to guide and check your learning 

Question #1

Pharmaco____________ is how the body effects a drug

Pharmaco____________ is how a drug effects the body

Question #2

What are the main tenants of pharmacokinetics?

A = ____________________________

D = ____________________________

M = ____________________________

E = _____________________________

Question #3

What are some of the ways that drug absorption differs in pediatric patients?

            Oral:

             IM:

             Topicals:

Question #4

What are some of the ways that drug distribution differs in pediatric patients?

Question #5

Drug metabolism is ______________ in pediatric patients relative to adult patients, partially due to differences in liver enzymes such as CYP450s

        a. increased

        b. decreased

        c. the same

        d. variable

Question #6

Important Elimination Equations 

      What is the name of the common equation used to estimate renal function in adults? ________________

                         Formula: ________________________________________________________________

      What is the name of the common equation used to estimate renal function in children? _________________

                         Formula: ________________________________________________________________

Question #7

Other Equations 

      How do you calculate Body Surface Area (BSA)? ____________________________________________

      How do you calculate Body Mass Index (BMI)? ___________________________________________

 

Practice Calculations

1. Calculate the weight-based dose of acetaminophen for a 15 kg patient

2. Calculate the eGFR of the following patient 

          8-year-old female; Height = 125 cm; Weight = 28kg; SCr = 0.3 mg/dL

3. Calculate the dose of valganciclovir for the following patient (Dose = 7 x BSA x CrCl)

         2-year-old male; Height =35 in; Weight = 25 lbs; SCr = 0.8 mg/dL

 

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